As we age, the natural production of collagen in our skin decreases, leading to fine lines, wrinkles, sagging, and a loss of elasticity. Collagen stimulation treatments using Poly-L-Lactic Acid (PLLA), Poly-D,L-Lactic Acid (PDLLA), Polycaprolactone ( PCL) or Calcium Hydroxylapatite (CaHA) offer a non-invasive, long-lasting solution to restoring the skin’s youthful appearance by stimulating the body’s natural collagen production. This innovative approach is gaining popularity for its ability to deliver gradual, natural-looking results.
What is PLLA, PDLLA , PCL and CaHA based fillers?
Poly-L-Lactic Acid-Sculptra (PLLA)
PLLA is a biocompatible and biodegradable synthetic polymer used in aesthetic medicine as a collagen stimulator rather than a traditional filler. Unlike gel-based fillers, PLLA does not provide immediate volume; instead, it gradually stimulates collagen production, leading to progressive improvement in skin volume, texture, and elasticity over time.
PLLA is ideal for individuals seeking:
Gradual improvement in skin firmness and volume
Treatment for deep wrinkles, folds, or hollow areas
A non-surgical alternative to facelifts or other invasive procedures
PLLA is best suited for patients with mild to moderate volume loss who want a natural, gradual enhancement.
Poly-D,L-Lactic Acid-Lenisna/Juvelook (PDLLA)
PDLLA is a newer-generation collagen stimulator, derived from PLLA but with a more controlled biodegradation process and an improved safety profile. Unlike pure PLLA, Lenisna contains a gel carrier, which means it provides some immediate volumization before transitioning into a full collagen-stimulating effect.
Best for:
Immediate and gradual volume restoration (cheeks, temples, nasolabial folds)
Skin rejuvenation and elasticity improvement
Minimizing deep wrinkles and fine lines
Long-lasting collagen stimulation
PDLLA-based biostimulator that offers both instant and progressive skin rejuvenation, making it an effective alternative for patients seeking immediate yet natural volume enhancement.
Polycaprolactone -Ellansè (PCL)
PCL is a biocompatible and biodegradable polymer that acts as both a dermal filler and collagen stimulator. It consists of PCL microspheres suspended in a carboxymethylcellulose (CMC) gel carrier, providing instant volumization while stimulating long-term collagen production for structural support and skin tightening.
Best for:
Immediate volume correction (due to the CMC gel carrier)
Deep structural support (jawline, temples, midface, nasolabial folds)
Long-term collagen stimulation for skin tightening and rejuvenation
Patients seeking a longer-lasting filler compared to other biostimulatory options
A key feature of PCL based biostimulator s its customizable longevity, as it comes in different variants (S, M, L, and E) that determine how long the effects last, ranging from 1 to 4 years. This makes PCL- based collagen stimulator a preferred choice for those looking for long-lasting, natural collagen stimulation with immediate results.
Calcium Hydroxyapatite-Radiesse (CaHA)
CaHA is a mineral-based biostimulatory filler composed of calcium hydroxyapatite microspheres suspended in a carboxymethylcellulose (CMC) gel carrier. Like PCL-based fillers, Radiesse provides instant volume while also stimulating collagen production over time.
Best for:
Immediate facial volumization (cheeks, jawline, nasolabial folds)
Hand rejuvenation (restoring volume to aging hands)
Skin tightening and elasticity improvement (when diluted for bio-revitalization)
CaHA based filler is widely used not only for facial contouring but also in a hyperdiluted form for skin tightening, neck rejuvenation, and cellulite reduction. Its ability to provide immediate structure and long-term collagen regeneration makes it a powerful tool in facial and body rejuvenation.
How Does PLLA Collagen Stimulation Work?
PLLA, PDLLA, Polycaprolactone (PCL), and Calcium Hydroxyapatite (CaHA) work by stimulating the skin’s natural collagen production process. Unlike traditional fillers that provide immediate volume by filling in wrinkles or folds, these biostimulatory fillers target the deeper layers of the skin to enhance collagen synthesis, improve skin quality, and restore volume naturally over time.
1. Injection Phase:
PLLA, PDLLA, PCL, and CaHA are injected into specific areas of concern, such as the face, neck, décolletage, or hands.
The injected solution initially provides temporary volume, which diminishes as the body absorbs the water content.
CaHA, PCL and PDLLA offers immediate structural support, whereas PLLA stimulate collagen production gradually for long-term rejuvenation.
2. Collagen Stimulation Phase:
Over several weeks, PLLA, PDLLA, PCL, and CaHA microparticles activate fibroblasts, prompting the natural production of new collagen.
This leads to a gradual improvement in skin volume, firmness, elasticity, and overall texture.
CaHA acts as a biostimulatory agent, promoting tissue regeneration while providing an initial lifting effect.
PCL has a unique ability to form a long-lasting collagen matrix, making it an excellent choice for deep structural support and prolonged results.
3. Long-Lasting Results:
The treatment is typically performed in a series of 2–4 sessions, spaced 4–6 weeks apart, to achieve optimal results.
As collagen production increases over time, the skin becomes plumper, firmer, and more youthful.
PLLA and PDLLA deliver results lasting up to 2–3 years, PCL provides effects lasting 3–4 years, while CaHA provides volume for 12–18 months with sustained collagen stimulation effects.
These advanced treatments offer a non-invasive, long-lasting solution for improving facial contours, restoring skin integrity, and enhancing natural beauty through collagen regeneration.
Benefits of
• Natural Results: Enhances skin volume and reduces wrinkles gradually, avoiding an
overfilled appearance.
• Long-Lasting Effects: Results can last for several years with proper maintenance.
• Minimally invasive with no need for incisions or downtime.
• Treats a variety of areas, including:
• Deep nasolabial folds (smile lines).
• Hollow temples and cheeks.
• Sagging jawline or chin.
• Aging skin on the neck, décolletage, and hands.
Collagen Stimulation Therapy Brisbane
Collagen Stimulation Therapy Brisbane
Recommended for the following conditions
Areas to be treated with
Collagen Stimulation Therapy Brisbane
Schedule your injection at a time when minor swelling or bruising will not disrupt your social obligations. Each time you are treated, outcomes may vary.
To lessen the likelihood of bleeding or bruising, discontinue use of blood thinning products for 10 days prior to treatment, if approved by your primary care provider. This includes aspirin, ibuprofen, naproxen, fish oil, St. John's Wort, flax, Vitamin E, Vitamin D, garlic, Ginkgo Biloba, ginseng, etc
Avoid injectables if you’ve had an infection, cold, virus, or flu in the past 30 days.
Delay treatment if you've had immunizations or are expecting them in the next 30 days.
Discontinue blood thinners (e.g., aspirin, ibuprofen) 10 days before treatment (with doctor approval).
Avoid alcohol 24 hours before or after treatment.
Notify your provider if you have a history of cold sores or open sores in the treatment area.
Alert us to any medical conditions or medications you’re taking.
Do not proceed with injectables if pregnant, breastfeeding, or allergic to any injectable components.
After PLLA gently massage the treated areas as instructed by your clinician, usually five minutes, five times a day for five days ( 5-5-5 rule).
No massage needed after Standard CaHa for volume correction and PCL based biostimulator.
Sometimes bumps may develop over 6-12 months and may resolve themselves. Sometimes they may require treatment.
If you have any concerns, please contact your treating doctor. Report any side effects to your treating doctor.
First 24 hours
Don’t apply make up
Don’t swim or exercise vigorously
Don’t expose yourself to extreme heat or cold
Don’t drink very hot beverages or alcohol
Arnica tablets if prone to bruising and swelling
Apply damp icy cloth if swelling or tenderness. Avoid direct contact of ice to skin as it may burn skin.
Try to sleep elevated if excessive swelling.
Over the next 2 days
Avoid all activities that would wrinkle your face and reduce product absorption evenly into your tissues. Use moisturiser cream to massage to reduce friction on face.
Sleep on your back so that skin will drape evenly
Over the next 7 days
After each treatment session, gently massage the treated areas at least daily. More often if lumps occur.
Massage in small rotatory rhythmic movement for 5-10 min.
Don’t use goggles for 4 weeks after treatment
Avoid excessive sun and UV lamp exposure until all swelling and redness resolved. Apply sunscreen before going out in sun
Results and Longevity
• Initial results, such as smoother and firmer skin, become visible after 4–6 weeks as collagen production increases.
• Full results are typically achieved 3–6 months after the final treatment session.
• The effects last up to 2–3 years, making it one of the longest-lasting non-surgical skin rejuvenation options.
Collagen Stimulation Therapy Brisbane
Before & After Care
Collagen Stimulation Therapy Brisbane
Frequently Asked Questions
Does Collagen Stimulation Therapy show lasting results?
Yes, it offers results that can last up to 2 years as it stimulates collagen production over time.
How does Collagen Stimulation Therapy work?
It involves injecting a biostimulatory (PLLA) filler that promotes natural collagen growth to restore volume and improve skin texture.
Does Collagen Stimulation Therapy hurt?
Mild discomfort may occur during the injection, but numbing creams are used to reduce any pain.
What are the disadvantages of Collagen Stimulation Therapy?
Temporary swelling, bruising, redness, or lumps; results take weeks to months to fully appear
Is it safe to get Collagen Stimulation Therapy?
Yes, it is a safe and effective procedure when performed by trained professionals.
Is it safe for all skin types and tones?
Yes, Collagen Stimulation Therapy with PLLA is safe and effective for all skin types and tones.
Who should avoid getting Collagen Stimulation Therapy with PLLA?
Individuals with autoimmune diseases, active infections, or a history of severe allergic reactions to Sculptra components should avoid the treatment. Pregnant or breastfeeding individuals are also not suitable candidates.
Collagen Stimulation Therapy Brisbane
Before & After Gallery
Why Choose Primavera Clinic for
At Primavera Clinic, our collagen stimulation treatments are tailored, medically led, and designed to restore your skin’s natural firmness and glow. We focus on subtle, natural-looking results using evidence-based techniques and a consultation-first approach. With expert care and customised plans, you’ll feel confident in every step of your skin journey.
Collagen Stimulation Therapy Brisbane
Book an initial consultation for $150 (1 hour) to create a tailored treatment plan for your skin needs and budget.
Disclaimer: Book your initial consultation with a qualified esthetician now to have your skin concerns assessed. Results may vary, depending on the individual. Primavera Clinic can consult with you to confirm if this treatment is right for you. The cost of the initial consultation cannot be substituted for the cost of treatment, as they are separate components of the overall process. Initial consultation typically involves an initial assessment, diagnosis, and discussion of treatment options, whereas the cost of treatment reflects the actual services or procedures provided to address the issue.